ACE Inhibitors and Weight Loss
Friday, April 24, 2009

A.C.E. inhibitors are a popular blood pressure medication but could they have an added benefit? Dr. Edward Hill looks at a study that suggests a link between these drugs and weight loss in todayís 60 Second Housecall.

Some popular blood pressure medications may help you lose weight and body fat.

Angiotensin-converting enzyme, or ACE, inhibitors and angiotensin II receptor blockers are drugs that help control blood pressure and reduce fluid buildup in the body.

Researchers in Australia examined mice that were missing a gene that encodes for angiotensin-converting enzyme. They discovered that those without the gene weighed 20 percent less.

The lightweight mice also had about 50 percent less body fat than their heavyweight counterparts, particularly in the belly area. However, both groups of mice seemed to eat and exercise the same amount, leading researchers to theorize that the slimmer mice might have a faster metabolism.

The researchers found that the ACE-deficient mice not only broke down fats faster in the liver, they processed blood sugars more quickly than the other mice, making them less likely to develop diabetes.

The study results demonstrate that an ACE deficiency leads to reduction in body fat accumulation in mice and suggests that drugs such as ACE inhibitors, might spark weight loss, especially in the midsection.

For North Mississippi Medical Center, Iím Dr. Edward Hill.